Side effects prednisolone to metabolism and endocrine system
Prednisone affects to all types of metabolic processes. Under the influence of dissolved proteins and their degradation products are used by the body to produce glucose. With long term use of prednisone in plasma may deficiency of proteins. And as prednisolone steroids in plasma norm is associated with proteins in their deficit appears toxic free progesterone. At deficiency of plasma protein is impaired growth of children and adolescents.
Mineral metabolism is disturbed due to the fact that the organism appears potassium (it reduces the ability Cytotoxic infarction) and calcium (formed osteoporosis is a thinning of the bones). In the body is delayed sodium and water are the causes edema.
On the part of the endocrine system is suppressed function of the hypothalami system. This leads to the violation of the adrenal glands and the formation of Cushing's syndrome, and also to suppress the secretion of the gonadotropins hormones of the pituitary gland, menstrual disorders and infertility in women. Disorders of carbohydrate metabolism cause the development of steroid diabetes, or manifestations previously asymptomatic flowed diabetes.
Side effects prednisolone - cardiovascular system
The loss of the body potassium affects the condition of the heart muscle (myocardium). This may result in cardiac arrhythmias, and bradycardia (slow heart rhythms, until the heart stops). The contractile ability of the heart can cause the development of symptoms of heart failure, when the heart is unable to cope with the load and the stagnation of blood in the peripheral blood vessels. The process is aggravated by the fact that the body is delayed sodium and water - it helps to increase the volume of circulating blood and further stagnation.
At the same time under the action of prednisone is a spasm of the blood vessels and increase blood pressure, it creates preconditions for the further stagnation of blood and its increased coagulability, that is the tendency to form blood clots. The coronary thrombosis and blood vessels of the brain - the main cause of heart attacks and strokes. However in patients with acute myocardial infarction in patients receiving prednisolone spreading hearth necrosis (death of tissue) and slowing the formation of scar tissue, which can lead to rupture of the heart muscle.
Prednisone side effects to other organs and systems
On the part of the gastrointestinal tract are possible violations of appetite, nausea, and vomiting, bloating, hiccups. Happen erosive and ulcerative defeat of the gastrointestinal tract and bleeding from this area, inflammation of the esophagus and pancreas, sometimes developed transient disturbances of liver function.
From the side of the loco-motors apparatus can occur osteoporosis (it may be accompanied by fractures), violations of the bone growth in children and adolescents, muscle weakness and a decrease in the amount of muscle (atrophy), the gap tendons, muscles and ligaments (they consist of connective tissue, which reduces its volume under the action of prednisone).
Reactions after Taking Prednisone, on the skin when applied topically prednisolone and injection may appear small hemorrhages, plots increased or decreased pigmentation, thinning of the skin (skin atrophy), stretch (a consequence of the gap collagen fibers), you may receive postural rash and fungal diseases.
Prednisone affects to all types of metabolic processes. Under the influence of dissolved proteins and their degradation products are used by the body to produce glucose. With long term use of prednisone in plasma may deficiency of proteins. And as prednisolone steroids in plasma norm is associated with proteins in their deficit appears toxic free progesterone. At deficiency of plasma protein is impaired growth of children and adolescents.
Mineral metabolism is disturbed due to the fact that the organism appears potassium (it reduces the ability Cytotoxic infarction) and calcium (formed osteoporosis is a thinning of the bones). In the body is delayed sodium and water are the causes edema.
On the part of the endocrine system is suppressed function of the hypothalami system. This leads to the violation of the adrenal glands and the formation of Cushing's syndrome, and also to suppress the secretion of the gonadotropins hormones of the pituitary gland, menstrual disorders and infertility in women. Disorders of carbohydrate metabolism cause the development of steroid diabetes, or manifestations previously asymptomatic flowed diabetes.
Side effects prednisolone - cardiovascular system
The loss of the body potassium affects the condition of the heart muscle (myocardium). This may result in cardiac arrhythmias, and bradycardia (slow heart rhythms, until the heart stops). The contractile ability of the heart can cause the development of symptoms of heart failure, when the heart is unable to cope with the load and the stagnation of blood in the peripheral blood vessels. The process is aggravated by the fact that the body is delayed sodium and water - it helps to increase the volume of circulating blood and further stagnation.
At the same time under the action of prednisone is a spasm of the blood vessels and increase blood pressure, it creates preconditions for the further stagnation of blood and its increased coagulability, that is the tendency to form blood clots. The coronary thrombosis and blood vessels of the brain - the main cause of heart attacks and strokes. However in patients with acute myocardial infarction in patients receiving prednisolone spreading hearth necrosis (death of tissue) and slowing the formation of scar tissue, which can lead to rupture of the heart muscle.
Prednisone side effects to other organs and systems
On the part of the gastrointestinal tract are possible violations of appetite, nausea, and vomiting, bloating, hiccups. Happen erosive and ulcerative defeat of the gastrointestinal tract and bleeding from this area, inflammation of the esophagus and pancreas, sometimes developed transient disturbances of liver function.
From the side of the loco-motors apparatus can occur osteoporosis (it may be accompanied by fractures), violations of the bone growth in children and adolescents, muscle weakness and a decrease in the amount of muscle (atrophy), the gap tendons, muscles and ligaments (they consist of connective tissue, which reduces its volume under the action of prednisone).
Reactions after Taking Prednisone, on the skin when applied topically prednisolone and injection may appear small hemorrhages, plots increased or decreased pigmentation, thinning of the skin (skin atrophy), stretch (a consequence of the gap collagen fibers), you may receive postural rash and fungal diseases.
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