Sunday, May 4, 2014

Lisinopril side effects contraindications and dosage for use

Lisinopril side effects
  • Decrease blood pressure, arrhythmias, chest pain, not often - orthostatic hypotension, and tachycardia.
  • Side effects to the nervous system: dizziness, headache, high fatigue, drowsiness, muscle twitching limbs and lips, not often - asthenia, Emotional Lability, confusion.
  • On digestive system: nausea, indigestion, loss of appetite, change in taste, abdominal pain, diarrhea, dry mouth.  From the side of hematopoiesis: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, anemia (reduction Hb, Erythrocytopenia).
  • Allergic reactions: angioneurotic swelling, skin rashes, itchy skin. Laboratory parameters: hyperkalemia, hyperuricemia;  increasing the activity of "liver" transaminases, hyperbilirubinemia.  Other: dry cough, decreased potency:  acute renal failure, swollen tongue, lips, and extremities. Other Lisinopril side effects: Developmental disorders of the kidneys of a fetus.

Lisinopril composition
(S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]-L-Proline . Crystalline powder white or almost white, odourless, soluble in water, sparingly soluble in methanol and practically insoluble in ethanol.

Lisinopril interaction with other drugs
gipotenzivny effect reinforce diuretics weakens - indomethacin. When combined with nitrates, propranolol and digoxin were observed clinically significant adverse pharmacokinetic interactions. Increases lithium toxicity. Potassium-sparing diuretics, potassium supplements and kalisodergaszczye means increased risk of hyperkalemia.

Lisinopril indications for use
Various forms of arterial hypertension (raising blood pressure), including renovascular (due sickness of the kidneys). Heart failure (in the complex therapy).

Lisinopril dosage for use
With arterial hypertension (persistent increase in blood pressure) drug is prescribed in the initial dose of 10 mg 1 time per day.  With the lack of expressiveness hypotensive (reducing blood pressure) effects, the dose of the product increase to 20-40 mg (up to 80 mg). In chronic heart failure appointed in the initial dose of 2.5 mg; supporting dose - 5-20 mg. For patients with disorders of water-electrolyte metabolism, renal failure, renovascular hypertension, also receiving diuretics initial dose of lisinopril is 2.5-5 mg. The drug is taken 1 time a day regardless of the meal.

Before treatment should be compensated for the loss of fluid and salts. With the utmost care appoint patients with impaired kidney function, also patients receiving diuretics and antidepressants. When used together with diuretics, vasodilators and beta-blockers effect of the product goes up, which is often used by doctors in the treatment of severe hypertension. With simultaneous use of analgesics anti-inflammatory effect of the product is reduced.

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